| Product Name | LDL Receptor antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [IgG-C7] to LDL ReceptorThe low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2 |
| Clone Number | IgG-C7 |
| Host Species | Mouse |
| Tested Applications | FACSICC/IFWB |
| FACS:1:200~1:500 ICC/IF:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanBovine |
| Concentration | 1mg/ml |
| Gene Synonyms | FH FHC |
|---|---|
| Target | LDL Receptor |
| Tissue Specificity | Lipoprotein, Low Density (LDL) Receptor |
| Cellular Localization | Found distributed from the plasma membrane to intracellular compartments. |
| Application Notes | FACS:1:200~1:500 ICC/IF:1:200~1:500 WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Upon receipt, store at –20°C. Avoid multiple freeze/thaw cycles. |
| Storage Buffer | Lyophilized from PBS, pH 7.4 containing 0.5% BSA. |
Data sheet for OM261360