MSH2

Catalog Number：OM638986

  • Fig1: Western blot analysis on (A) A375, (B) A431, (C) SW480, and (D) HeLa cell lysates using anti-MSH2.

Product Profile

Product Name MSH2
Antibody Type Primary Antibodies
Product description 
MutS homologue 2 (MSH2) is a DNA mismatch repair protein in the MutS family (1). MSH2 forms two different heterodimers: MutS alpha (MSH2-MSH6) and MutS beta (MSH2-MSH3) that bind to DNA mismatches thereby initiating DNA repair. (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA (2). MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long (2). Heterozygous mutations in the MSH2 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 and MSH6 (3, 4). MutS alpha may also play a role in DNA homologous recombination repair (2).
Immunogen 
peptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBFC
WB:1:1,000
FC:1:10-100
Species Reactivity

Human
Concentration 1 mg/mL.

Target Information

Alternative Names
BAT26 antibody COCA 1 antibody COCA1 antibody DNA mismatch repair protein Msh2 antibody FCC 1 antibody FCC1 antibody hMSH2 antibody HNPCC 1 antibody HNPCC antibody HNPCC1 antibody LCFS2 antibody MSH 2 antibody Msh2 antibody MSH2_HUMAN antibody MutS homolog 2 antibody MutS homolog 2 colon cancer nonpolyposis type 1 antibody MutS protein homolog 2 antibody
Molecular Weight(MW) 100 kDa
Cellular Localization Nucleus

Database Links

SwissProt ID P43246

Application

  • Application

    Fig1: Western blot analysis on (A) A375, (B) A431, (C) SW480, and (D) HeLa cell lysates using anti-MSH2.

Positive Control Hela, A375, A431, SW480.
Application Notes
WB:1:1,000
FC:1:10-100

Additional Information

Form Liquid
Storage Instructions Store at -20 ℃. Stable for 12 months from date of receipt
Storage Buffer 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM638986
  • Price: $336.00
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  • Lead time: 4~6 Week

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