All products Antibodies NDP Antibody (N-term)

NDP Antibody (N-term)

Catalog Number：OM215094

  • Western blot analysis of NDP Antibody (N-term) in Y79 cell line lysates (35ug/lane). NDP (arrow) was detected using the purified Pab.

  • Formalin-fixed and paraffin-embedded human brain tissue reacted with NDP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

  • NDP Antibody (N-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Product Profile

Product Name NDP Antibody (N-term)
Antibody Type Primary Antibodies

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WBIHCFC
WB~~1:100~500 IHC~~1:50~100 FC~~1:10~50:
Species Reactivity

Human
Concentration 1 mg/ml
Purification

Target Information

Gene Synonyms
EVR2
Alternative Names
NDP
EVR2
Norrin
Norrie disease protein
X-linked exudative vitreoretinopathy 2 protein
Molecular Weight(MW) 15044 Da
Function
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction
Tissue Specificity Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain
Cellular Localization Secreted.

Database Links

Entrez Gene 4693

Application

  • Application

    Western blot analysis of NDP Antibody (N-term) in Y79 cell line lysates (35ug/lane). NDP (arrow) was detected using the purified Pab.

  • Application

    Formalin-fixed and paraffin-embedded human brain tissue reacted with NDP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

  • Application

    NDP Antibody (N-term) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Application Notes
WB~~1:100~500 IHC~~1:50~100 FC~~1:10~50:

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM215094
  • Price: $336.00
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  • Lead time: 2~3 Week

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