All products Antibodies NOD1 Antibody (C-term)

NOD1 Antibody (C-term)

Catalog Number：OM215476

  • NOD1 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the NOD1 antibody detected the NOD1 protein (arrow).

  • NOD1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOD1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

  • NOD1 Antibody (C-term) western blot analysis in HL-60,CEM cell line lysates (35ug/lane).This demonstrates the NOD1 antibody detected the NOD1 protein (arrow).

  • Confocal immunofluorescent analysis of NOD1 Antibody (C-term)(Cat#AP11805b) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

  • NOD1 Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Product Profile

Product Name NOD1 Antibody (C-term)
Antibody Type Primary Antibodies

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WBIHCIFFC
WB~~1:100~500 IHC~~1:10~50 IF~~1:10~50 FC~~1:10~50:
Species Reactivity

Human
Concentration 1 mg/ml
Purification

Target Information

Gene Synonyms
CARD4
Alternative Names
NOD1
CARD4
Nucleotide-binding oligomerization domain-containing protein 1
Caspase recruitment domain-containing protein 4
Molecular Weight(MW) 107691 Da
Function
Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection
Tissue Specificity Highly expressed in adult heart, skeletal muscle, pancreas, spleen and ovary. Also detected in placenta, lung, liver, kidney, thymus, testis, small intestine and colon
Cellular Localization Cytoplasm. Cell membrane. Apical cell membrane. Basolateral cell membrane. Note=Detected in the cytoplasm and at the cell membrane. Following bacterial infection, localizes to bacterial entry sites in the cell membrane. Recruited to the basolateral and apical membranes in polarized epithelial cells

Database Links

Entrez Gene 10392
Nucleotide Accession NP_006083.1

Application

  • Application

    NOD1 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the NOD1 antibody detected the NOD1 protein (arrow).

  • Application

    NOD1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of NOD1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

  • Application

    NOD1 Antibody (C-term) western blot analysis in HL-60,CEM cell line lysates (35ug/lane).This demonstrates the NOD1 antibody detected the NOD1 protein (arrow).

  • Application

    Confocal immunofluorescent analysis of NOD1 Antibody (C-term)(Cat#AP11805b) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

  • Application

    NOD1 Antibody (C-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.

Application Notes
WB~~1:100~500 IHC~~1:10~50 IF~~1:10~50 FC~~1:10~50:

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM215476
  • Price: $336.00
  • Discount Price
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  • Lead time: 2~3 Week

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