All products Antibodies Rabbit anti-AIRE polyclonal antibody - middle region

Rabbit anti-AIRE polyclonal antibody - middle region

Catalog Number：OM105551

  • 0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: Human Placenta

Product Profile

Product Name Rabbit anti-AIRE polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-AIRE antibody: synthetic peptide directed towards the middle region of human AIRE

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

Guinea PigHorseHuman
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol AIRE
Gene Synonyms
AIRE1
APECED
APS1
APSI
PGA1
Gene Full Name Autoimmune regulator
Gene Summary
The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alternative Names
AIRE1
APECED
APS1
APSI
PGA1
Molecular Weight(MW) 58kDa
Sequence 545 amino acids

Database Links

Entrez Gene 326
SwissProt ID O43918
Protein Accession NP_000374

Application

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: Human Placenta

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105551
  • Price: $336.00
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  • Lead time: 2~3 Week

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