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All products
Antibodies
Rabbit anti-BRCA1 polyclonal antibody - N-terminal region
0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: ACHN cell lysate
Product Profile
| Product Name | Rabbit anti-BRCA1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-BRCA1 antibody: synthetic peptide directed towards the N terminal of human BRCA1 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | BRCA1 |
|---|---|
| Gene Synonyms | BRCAI BRCC1 IRIS PSCP RNF53 PNCA4 BROVCA1 PPP1R53 |
| Gene Full Name | Breast cancer 1, early onset |
| Gene Summary | The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. |
| Alternative Names | BRCAI BRCC1 IRIS PSCP RNF53 PNCA4 BROVCA1 PPP1R53 |
| Molecular Weight(MW) | 76kDa |
| Sequence | 680 amino acids |
Database Links
| Entrez Gene | 672 |
|---|---|
| SwissProt ID | P38398 |
| Protein Accession | NP_009229 |
Application
-
Western blot
0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: ACHN cell lysate
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
- Related products
- Anti-BRCA1 antibody OM642668
- Cyclin E2 Antibody OM276534
- Cyclin E1 Antibody OM276533
- BRCA1 Antibody OM272686
- BRCA1 Antibody OM272683
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