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All products
Antibodies
Rabbit anti-CRK polyclonal antibody - C-terminal region
Titration: 1.0 ug/ml
Positive Control: Transfected 293T
Product Profile
| Product Name | Rabbit anti-CRK polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | |
WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | CRK |
|---|---|
| Gene Synonyms | CRKII p38 |
| Gene Full Name | V-crk sarcoma virus CT10 oncogene homolog (avian) |
| Gene Summary | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Alternative Names | CRKII p38 |
| Molecular Weight(MW) | 34kDa |
| Sequence | 304 amino acids |
Database Links
| Entrez Gene | 1398 |
|---|---|
| SwissProt ID | P46108 |
| Protein Accession | NP_058431 |
Application
-
Western blot
Titration: 1.0 ug/ml
Positive Control: Transfected 293T
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.
- Related products
- Rabbit anti-CrkII (Phospho-Tyr221) polyclonal antibody OM123422
- Rabbit anti-CrkII polyclonal antibody OM123419
- Rabbit anti-CRK polyclonal antibody - C-terminal region OM105178
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