All products Antibodies Rabbit anti-FAS polyclonal antibody - middle region

Rabbit anti-FAS polyclonal antibody - middle region

Catalog Number：OM105196

  • 0.2-1 ug/ml
    Positive Control: Human Live

Product Profile

Product Name Rabbit anti-FAS polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-FAS antibody: synthetic peptide directed towards the middle region of human FAS

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol FAS
Gene Synonyms
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Gene Full Name Fas (TNF receptor superfamily, member 6)
Gene Summary
FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alternative Names
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Molecular Weight(MW) 36kDa
Sequence 335 amino acids

Database Links

Entrez Gene 355
SwissProt ID P25445
Protein Accession NP_000034

Application

  • Western blot

    0.2-1 ug/ml
    Positive Control: Human Live

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105196
  • Price: $336.00
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