All products Antibodies Rabbit anti-FKBP4 polyclonal antibody - C-terminal region

Rabbit anti-FKBP4 polyclonal antibody - C-terminal region

Catalog Number：OM105147

  • Sample Type: Mouse Brain Slices 
    Red: primary
    Blue: DAPI
    Primary
    Dilution: 1:400 
    Secondary Antibody: Anti-Rabbit IgG Alexa 594
    Secondary
    Dilution: 1:400 
    Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt 
    University of Seville

  • 0.2-1 ug/ml
    Positive Control: 721_B cell lysate

Product Profile

Product Name Rabbit anti-FKBP4 polyclonal antibody - C-terminal region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-FKBP4 antibody: synthetic peptide directed towards the C terminal of human FKBP4

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIHC
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol FKBP4
Gene Synonyms
FKBP52
FKBP59
HBI
Hsp56
PPIase
p52
FKBP51
Gene Full Name FK506 binding protein 4, 59kDa
Gene Summary
FKBP4 is a component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. It may have a rotamase activity. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alternative Names
FKBP52
FKBP59
HBI
Hsp56
PPIase
p52
FKBP51
Molecular Weight(MW) 52kDa
Sequence 459 amino acids

Database Links

Entrez Gene 2288
SwissProt ID P30416
Protein Accession NP_002005

Application

  • Immunohistochemical

    Sample Type: Mouse Brain Slices 
    Red: primary
    Blue: DAPI
    Primary
    Dilution: 1:400 
    Secondary Antibody: Anti-Rabbit IgG Alexa 594
    Secondary
    Dilution: 1:400 
    Image Submitted By: Adahir Labrador-Garrido and Cintia Roodveldt 
    University of Seville

  • Western blot

    0.2-1 ug/ml
    Positive Control: 721_B cell lysate

Application Notes
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105147
  • Price: $336.00
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  • Lead time: 2~3 Week

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