All products Antibodies Rabbit anti-NOTCH4 polyclonal antibody - middle region

Rabbit anti-NOTCH4 polyclonal antibody - middle region

Catalog Number：OM105615

  • Immunohistochemistry with Colon, submucosal plexus tissue at an antibody concentration of 5ug/ml using anti-NOTCH4 antibody

  • 0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: HepG2 cell lysate

Product Profile

Product Name Rabbit anti-NOTCH4 polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen 
The immunogen for anti-NOTCH4 antibody: synthetic peptide directed towards the middle region of human NOTCH4

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WB
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

BovineHorseHumanPig
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol NOTCH4
Gene Synonyms
FLJ16302
INT3
MGC74442
NOTCH3
Gene Full Name Notch 4
Gene Summary
NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alternative Names
INT3
NOTCH4
Molecular Weight(MW) 58kDa
Sequence 2003 amino acids

Database Links

Entrez Gene 4855
SwissProt ID Q99466
Protein Accession NP_004548

Application

  • Immunohistochemistry

    Immunohistochemistry with Colon, submucosal plexus tissue at an antibody concentration of 5ug/ml using anti-NOTCH4 antibody

  • Western blot

    0.2-1 ug/ml
    ELISA Titer: 1:62500
    Positive Control: HepG2 cell lysate

Application Notes
WB:1:500~1:2000
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM105615
  • Price: $336.00
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