All products Antibodies SHP-1(PTPN6)

SHP-1(PTPN6)

Catalog Number：OM638898

  • Fig1: Western blot analysis of SHP1 on mouse spleen tissue lysate using anti- SHP1 antibody at 1/5,000 dilution.

  • Fig2: ICC staining SHP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Fig3: ICC staining SHP1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Fig4: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Fig5: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Fig6: Immunohistochemical analysis of paraffin-embedded rat spinal cord tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Fig7: Flow cytometric analysis of Jurkat cells with SHP1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).

Product Profile

Product Name SHP-1(PTPN6)
Antibody Type Primary Antibodies
Product description 
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.
Immunogen 
Recombinant protein

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBICCIHCFC
WB:1:500~1:2000
ICC:1:200~1:500
IHC:1:50~1:200
FC:1:200~1:500
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

HumanMouseRat
Concentration 1 mg/mL.

Target Information

Alternative Names
70Z-SHP antibody EC 3.1.3.48 antibody HCP antibody HCPH antibody Hematopoietic cell phosphatase antibody Hematopoietic cell protein tyrosine phosphatase antibody Hematopoietic cell protein-tyrosine phosphatase antibody HPTP1C antibody Protein tyrosine phosphatase 1C antibody Protein tyrosine phosphatase non receptor type 6 antibody Protein tyrosine phosphatase SHP1 antibody Protein-tyrosine phosphatase 1C antibody protein-tyrosine phosphatase SHP 1 antibody Protein-tyrosine phosphatase SHP-1 antibody PTN6_HUMAN antibody PTP 1C antibody PTP-1C antibody PTP1C antibody Ptpn6 antibody SH PTP 1 antibody SH PTP1 antibody SH-PTP1 antibody SHP 1 antibody SHP 1L antibody SHP1 antibody SHP1L antibody tyrosine protein phosphatase non receptor type 6 antibody Tyrosine-protein phosphatase non-receptor type 6 antibody
Molecular Weight(MW) 68 kDa
Cellular Localization Cytoplasm. Nucleus.

Database Links

SwissProt ID P29350
P29351
P81718

Application

  • Application

    Fig1: Western blot analysis of SHP1 on mouse spleen tissue lysate using anti- SHP1 antibody at 1/5,000 dilution.

  • Application

    Fig2: ICC staining SHP1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig3: ICC staining SHP1 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig4: Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Application

    Fig5: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Application

    Fig6: Immunohistochemical analysis of paraffin-embedded rat spinal cord tissue using anti- SHP1 antibody. Counter stained with hematoxylin.

  • Application

    Fig7: Flow cytometric analysis of Jurkat cells with SHP1 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).

Positive Control Mouse spleen tissue lysate, A549, Hela, Jurkat, rat spinal cord tissue, human tonsil tissue, human spleen tissue.
Application Notes
WB:1:500~1:2000
ICC:1:200~1:500
IHC:1:50~1:200
FC:1:200~1:500
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

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  • Catalog Number: OM638898
  • Price: $336.00
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  • Lead time: 4~6 Week

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