nNOS Antibody (Center)

Product Profile

Product Name	nNOS Antibody (Center)
Antibody Type	Primary Antibodies

Key Feature

Clonality	Polyclonal
Isotype	Ig
Host Species	Rabbit
Tested Applications	WBFC
	WB~~1:100~500 FC~~1:10~50:
Species Reactivity	Human
Concentration	1 mg/ml
Purification

Target Information

Alternative Names	NOS1 Nitric oxide synthase brain Constitutive NOS NC-NOS NOS type I Neuronal NOS Peptidyl-cysteine S-nitrosylase NOS1 bNOS
Molecular Weight(MW)	160970 Da
Function	Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR
Tissue Specificity	Isoform 1 is ubiquitously expressed: detected in skeletal muscle and brain, also in testis, lung and kidney, and at low levels in heart, adrenal gland and retina. Not detected in the platelets. Isoform 3 is expressed only in testis. Isoform 4 is detected in testis, skeletal muscle, lung, and kidney, at low levels in the brain, but not in the heart and adrenal gland
Cellular Localization	Cell membrane, sarcolemma; Peripheral membrane protein. Cell projection, dendritic spine (By similarity). Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines (By similarity)

Database Links

Entrez Gene	4842

Application

Application Notes	WB~~1:100~500 FC~~1:10~50:

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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• Data sheet for OM215481