p-c-Myc Antibody (Ser 373)

Product Profile

Product Name	p-c-Myc Antibody (Ser 373)
Antibody Type	Tags Antibodies
Modification Notes	c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	IFIHC
	recommended for detection of Ser 373 phosphorylated c-Myc of mouse, rat and human origin by IF and IHC(P):
Species Reactivity	HumanMouseRat
Concentration	1mg/ml
Purification	Affinity purified

Target Information

Alternative Names	epitope corresponding to phosphorylated Ser 373 of c-Myc of human origin
Tissue Specificity	epitope corresponding to phosphorylated Ser 373 of c-Myc of human origin

Database Links

Entrez Gene	4609

Application

Application Notes	recommended for detection of Ser 373 phosphorylated c-Myc of mouse, rat and human origin by IF and IHC(P):

Additional Information

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Question type：
• Enter the charactors： Generate another
• Submit the question

• Data sheet for OM197734