Western blot
Titration: 1.0 ug/mlPositive Control: Mouse Heart| Product Name | Rabbit anti-Accn2 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AI843610, ASIC, ASIC1, ASIC1a, B530003N02Rik, BNaC2, Accn2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineHumanMouseRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Accn2 |
|---|---|
| Gene Synonyms | AI843610 ASIC ASIC1 ASIC1a B530003N02Rik BNaC2 |
| Gene Full Name | Amiloride-sensitive cation channel 2, neuronal |
| Gene Summary | Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear. |
| Alternative Names | AI843610 ASIC ASIC1 ASIC1a B530003N02Rik BNaC2 Accn2 |
| Molecular Weight(MW) | 60kDa |
| Sequence | 526 amino acids |
Western blot
Titration: 1.0 ug/mlPositive Control: Mouse Heart| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
