NR4A3 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NR4A3 may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between NR4A3 gene and other genes.