amino acids 222-259 within an internal region of NOR-1 of human origin.
Key Feature
Clonality
Monoclonal
Isotype
IgG1, k
Host Species
Mouse
Tested Applications
ICC/IFWB
WB:1:100-1:1000 ICC/IF:1:50-1:500
Species Reactivity
HumanMousePorcineRat
Concentration
0.1mg/ml
Purification
Affinity purified
Target Information
Gene Symbol
NR4A3
Gene Synonyms
CHN CSMF NOR1 MINOR
Gene Full Name
nuclear receptor subfamily 4 group A member 3
Gene Summary
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Molecular Weight(MW)
68 kDa
Cellular Localization
Nucleus
Application
WB
Western blot analysis of NOR-1 expression in non-transfected:(A) and mouse NOR-1 transfected: (B) 293
whole cell lysates.
ICC/IF
Immunofluorescence staining of formalin-fixed A-431 cells showing nuclear localization.
Application Notes
WB:1:100-1:1000 ICC/IF:1:50-1:500
Additional Information
Form
Liquid
Storage Instructions
Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required.
Storage Buffer
Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1%sodium azide and 0.1% gelatin.