Nuclear receptor subfamily 4 group A member 3, Mitogen-induced nuclear orphan receptor, Neuron-derived orphan receptor 1, Nuclear hormone receptor NOR-1, NR4A3, CHN, CSMF, MINOR, NOR1, TEC
Product description
This gene encodes a member of the steroid-thyroid
hormone-retinoid receptor superfamily. The encoded protein may act
as a transcriptional activator. The protein can efficiently bind
the NGFI-B Response Element (NBRE). Three different versions of
extraskeletal myxoid chondrosarcomas (EMCs) are the result of
reciprocal translocations between this gene and other genes. The
translocation breakpoints are associated with Nuclear Receptor
Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing
Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II,
TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome
17), or Transcription factor 12 (on chromosome 15). Multiple
transcript variants encoding different isoforms have been found for
this gene.1) Novak, G., et al. Genes Brain Behav. 9(8):910-917(2010)
Immunogen
This NR4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human NR4A3.
Western blot analysis in HepG2 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.