Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: COLO205 cell lysate| Product Name | Rabbit anti-PLEKHO1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CKIP-1, OC120, RP11-458I7.3 |
| Immunogen | The immunogen for anti-PLEKHO1 antibody: synthetic peptide directed towards the N terminal of human PLEKHO1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PLEKHO1 |
|---|---|
| Gene Synonyms | CKIP-1 OC120 RP11-458I7.3 |
| Gene Full Name | Pleckstrin homology domain containing, family O member 1 |
| Gene Summary | PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. |
| Alternative Names | CKIP-1 OC120 RP11-458I7.3 |
| Molecular Weight(MW) | 46kDa |
| Sequence | 409 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:62500Positive Control: COLO205 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
