Immunohistochemical
LiveWestern blot
Host: Rabbit Target Name: CHAD Sample Tissue: Human Adult Placenta Antibody Dilution: 1.0ug/mlWestern blot
0.2-1 ug/mlPositive Control: Jurkat cell lysate| Product Name | Rabbit anti-SIGIRR polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC110992, TIR8 |
| Immunogen | The immunogen for anti-SIGIRR antibody: synthetic peptide directed towards the C terminal of human SIGIRR |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMouseZebra Fish |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SIGIRR |
|---|---|
| Gene Synonyms | MGC110992 TIR8 |
| Gene Full Name | Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Gene Summary | SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Alternative Names | MGC110992 TIR8 |
| Molecular Weight(MW) | 25kDa |
| Sequence | 224 amino acids |
| Entrez Gene | 59307 |
|---|---|
| Protein Accession | XP_001129013 |
Immunohistochemical
Live
Western blot
Host: Rabbit Target Name: CHAD Sample Tissue: Human Adult Placenta Antibody Dilution: 1.0ug/ml
Western blot
0.2-1 ug/mlPositive Control: Jurkat cell lysate| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
