Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate| Product Name | Rabbit anti-CENTG1 polyclonal antibody - middle region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AGAP2, FLJ16430, GGAP2, KIAA0167, PIKE, CENTG1 |
| Immunogen | The immunogen for anti-CENTG1 antibody: synthetic peptide directed towards the middle region of human CENTG1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | CENTG1 |
|---|---|
| Gene Synonyms | AGAP2 FLJ16430 GGAP2 KIAA0167 PIKE CENTG1 |
| Gene Full Name | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| Gene Summary | CENTG1 is a GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
| Alternative Names | AGAP2 FLJ16430 GGAP2 KIAA0167 PIKE CENTG1 |
| Molecular Weight(MW) | 90kDa |
| Sequence | 836 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
