Western blot
0.2-1 ug/mlPositive Control: Human Live| Product Name | Rabbit anti-PIAS2 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX |
| Immunogen | The immunogen for anti-PIAS2 antibody: synthetic peptide directed towards the N terminal of human PIAS2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMouseRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | PIAS2 |
|---|---|
| Gene Synonyms | MGC102682 MIZ1 PIASX-ALPHA PIASX-BETA SIZ2 ZMIZ4 miz DIP MIZ ARIP3 PIASX |
| Gene Full Name | Protein inhibitor of activated STAT, 2 |
| Gene Summary | Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. |
| Alternative Names | MGC102682 MIZ1 PIASX-ALPHA PIASX-BETA SIZ2 ZMIZ4 miz DIP MIZ ARIP3 PIASX |
| Molecular Weight(MW) | 63kDa |
| Sequence | 572 amino acids |
Western blot
0.2-1 ug/mlPositive Control: Human Live| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
