Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human LiveWB
Treatment with ICA and PNS reduced MIPT3 and increased Oasl1 and TCHP protein levels. N=6 in each group.| Product Name | Rabbit anti-TCHP polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-TCHP antibody: synthetic peptide directed towards the C terminal of human TCHP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineDogGuinea PigHorseHumanMousePigRabbitRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TCHP |
|---|---|
| Gene Synonyms | MGC10854 TpMs |
| Gene Full Name | Trichoplein, keratin filament binding |
| Gene Summary | TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. |
| Alternative Names | MGC10854 TpMs |
| Molecular Weight(MW) | 61kDa |
| Sequence | 498 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Human Live
WB
Treatment with ICA and PNS reduced MIPT3 and increased Oasl1 and TCHP protein levels. N=6 in each group.| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
