Application
MAP3K11 (Cat. #AM1906a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MAP3K11 antibody detected the MAP3K11 protein (arrow).| Product Name | MAP3K11 Antibody (ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 230CT5.3.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MLK3, PTK1, SPRK |
|---|---|
| Alternative Names | MAP3K11 MLK3 PTK1 SPRK Mitogen-activated protein kinase kinase kinase 11 Mixed lineage kinase 3 Src-homology 3 domain-containing proline-rich kinase |
| Molecular Weight(MW) | 92688 Da |
| Function | Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7 Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle |
| Tissue Specificity | Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain |
| Cellular Localization | Cytoplasm, cytoskeleton, centrosome. Note=Location is cell cycle dependent |
| Entrez Gene | 4296 |
|---|---|
| Nucleotide Accession | NP_002410.1 |
Application
MAP3K11 (Cat. #AM1906a) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MAP3K11 antibody detected the MAP3K11 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
