Application
MARCKSL1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MARCKSL1 antibody detected the MARCKSL1 protein (arrow).| Product Name | MARCKSL1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MARCKSL1; MLP; MRP; MARCKS-related protein; MARCKS-like protein 1; Macrophage myristoylated alanine-rich C kinase substrate |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MLP MRP |
|---|---|
| Alternative Names | MARCKSL1 MLP MRP MARCKS-related protein MARCKS-like protein 1 Macrophage myristoylated alanine-rich C kinase substrate |
| Molecular Weight(MW) | 19529 Da |
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) |
| Tissue Specificity | This MARCKSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the C-terminal region of human MARCKSL1. |
| Cellular Localization | Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity) In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity) |
| Entrez Gene | 65108 |
|---|---|
| Nucleotide Accession | NP_075385.1 |
Application
MARCKSL1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MARCKSL1 antibody detected the MARCKSL1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
