Application
MDM4 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the MDM4 antibody detected the MDM4 protein (arrow).| Product Name | MDM4 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MDM4; MDMX; Protein Mdm4; Protein Mdmx; Double minute 4 protein; Mdm2-like p53-binding protein; p53-binding protein Mdm4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | MDMX |
|---|---|
| Alternative Names | MDM4 MDMX Protein Mdm4 Protein Mdmx Double minute 4 protein Mdm2-like p53-binding protein p53-binding protein Mdm4 |
| Molecular Weight(MW) | 54864 Da |
| Function | Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions |
| Tissue Specificity | Expressed in all tissues tested with high levels in thymus |
| Cellular Localization | Nucleus. |
| Entrez Gene | 4194 |
|---|---|
| Nucleotide Accession | NP_002384.2 |
Application
MDM4 Antibody (Center) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the MDM4 antibody detected the MDM4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
