Application
MEN1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MEN1 antibody detected the MEN1 protein (arrow).Application
Confocal immunofluorescent analysis of MEN1 Antibody (N-term)(Cat#AP13747a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).| Product Name | MEN1 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MEN1; SCG2; Menin |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIF |
| WB:1:100~500 IF |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SCG2 |
|---|---|
| Alternative Names | MEN1 SCG2 Menin |
| Molecular Weight(MW) | 68023 Da |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Nucleus. Note=Concentrated in nuclear body- like structures. Relocates to the nuclear matrix upon gamma irradiation |
| Entrez Gene | 4221 |
|---|---|
| Nucleotide Accession | NP_000235.2 NP_570716.1 NP_570711.1 NP_570712.1 |
Application
MEN1 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MEN1 antibody detected the MEN1 protein (arrow).
Application
Confocal immunofluorescent analysis of MEN1 Antibody (N-term)(Cat#AP13747a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).| Application Notes | WB:1:100~500 IF |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
