Application
Western blot analysis on (A) Jurkat, (B) 293T, (C) K562, (D) A431 and (E) HeLa cell lysates using anti-Menin RabMAb (Cat. #AJ1473a).Application
Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Menin RabMAb (Cat. #AJ1473a).Application
Immunohistochemical analysis of paraffin-embedded human papillary carcinoma of thyroid gland using anti-Menin RabMAb (Cat. #AJ1473a).Application
Immunofluorescent staining of HeLa cells using anti-Menin RabMAb (cat. #2817).| Product Name | Menin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR3986 |
| Host Species | Rabbit |
| Tested Applications | WBIHCIF |
| WB:1:500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | SCG2 |
|---|---|
| Molecular Weight(MW) | 68023 Da |
| Function | Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair |
| Tissue Specificity | Ubiquitous. |
| Cellular Localization | Nucleus. Note=Concentrated in nuclear body- like structures. Relocates to the nuclear matrix upon gamma irradiation |
| Entrez Gene | 4221 |
|---|
Application
Western blot analysis on (A) Jurkat, (B) 293T, (C) K562, (D) A431 and (E) HeLa cell lysates using anti-Menin RabMAb (Cat. #AJ1473a).
Application
Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-Menin RabMAb (Cat. #AJ1473a).
Application
Immunohistochemical analysis of paraffin-embedded human papillary carcinoma of thyroid gland using anti-Menin RabMAb (Cat. #AJ1473a).
Application
Immunofluorescent staining of HeLa cells using anti-Menin RabMAb (cat. #2817).| Application Notes | WB:1:500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
