Application
Mouse Bmi1 antibody (Cat. #AM1980b) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Mouse Bmi1 antibody detected the Mouse Bmi1 protein (arrow).| Product Name | Bmi1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Bmi1; Bmi-1; Pcgf4; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Clone Number | 353CT22.4.4 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:200~1600 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Bmi-1 Pcgf4 |
|---|---|
| Alternative Names | Bmi1 Bmi-1 Pcgf4 Polycomb complex protein BMI-1 Polycomb group RING finger protein 4 |
| Molecular Weight(MW) | 36708 Da |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity) |
| Tissue Specificity | Detected in most organs with high expression levels in thymus, heart, brain and testis |
| Cellular Localization | Nucleus. Cytoplasm (By similarity). |
| Entrez Gene | 12151 |
|---|---|
| Nucleotide Accession | NP_031578.2 |
Application
Mouse Bmi1 antibody (Cat. #AM1980b) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the Mouse Bmi1 antibody detected the Mouse Bmi1 protein (arrow).| Application Notes | WB:1:200~1600 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
