Application
Mouse Irgm1 (Cat. #AM2003b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the IRGM1 antibody detected the Irgm1 protein (arrow).| Product Name | Irgm1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Irgm1; Ifi1; Iigp3; Irgm; Immunity-related GTPase family M protein 1; Interferon-inducible GTPase 3; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 403CT8.5.5 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Ifi1 Iigp3 Irgm |
|---|---|
| Alternative Names | Irgm1 Ifi1 Iigp3 Irgm Immunity-related GTPase family M protein 1 Interferon-inducible GTPase 3 Interferon-inducible protein 1 LPS-stimulated RAW 264.7 macrophage protein 47 |
| Molecular Weight(MW) | 46552 Da |
| Function | Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion |
| Tissue Specificity | Expressed in lung and primary macrophages. |
| Cellular Localization | Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Late endosome membrane Cell projection, phagocytic cup. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing phagosomes Association with phagosomes is dependent on nucleotide-binding but is IFNG-independent. Preferentially associated with cis- and medial-Golgi. Also detected in late endosomes and lysosomes |
| Entrez Gene | 15944 |
|---|---|
| Nucleotide Accession | NP_032352.1 |
Application
Mouse Irgm1 (Cat. #AM2003b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the IRGM1 antibody detected the Irgm1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS. |
