Application
MSH3 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MSH3 antibody detected the MSH3 protein (arrow).| Product Name | MSH3 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MSH3; DUC1; DUG; DNA mismatch repair protein Msh3; Divergent upstream protein; Mismatch repair protein 1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | DUC1 DUG |
|---|---|
| Alternative Names | MSH3 DUC1 DUG DNA mismatch repair protein Msh3 Divergent upstream protein Mismatch repair protein 1 |
| Molecular Weight(MW) | 127412 Da |
| Function | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion- deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis |
| Tissue Specificity | This MSH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-462 amino acids from the Central region of human MSH3. |
| Entrez Gene | 4437 |
|---|---|
| Nucleotide Accession | NP_002430.3 |
Application
MSH3 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MSH3 antibody detected the MSH3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
