Application
MVP Antibody (N-term)(Ascites)(Cat. #AM2146a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MVP antibody detected the MVP protein (arrow).| Product Name | MVP Antibody (N-term) (Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MVP; LRP; Major vault protein; Lung resistance-related protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 599CT2.4.1 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~1600 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | LRP |
|---|---|
| Alternative Names | MVP LRP Major vault protein Lung resistance-related protein |
| Molecular Weight(MW) | 99327 Da |
| Function | Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells |
| Cellular Localization | Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment |
| Entrez Gene | 9961 |
|---|---|
| Nucleotide Accession | NP_005106.2 |
Application
MVP Antibody (N-term)(Ascites)(Cat. #AM2146a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MVP antibody detected the MVP protein (arrow).| Application Notes | WB:1:100~1600 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
