Application
MYO1C (Cat. #AM1905a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the MYO1C antibody detected the MYO1C protein (arrow).| Product Name | MYO1C Antibody (ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MYO1C; Unconventional myosin-Ic; Myosin I beta |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 221CT4.7.2.4 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MYO1C Unconventional myosin-Ic Myosin I beta |
|---|---|
| Molecular Weight(MW) | 121682 Da |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity) |
| Tissue Specificity | This MYO1C monoclonal antibody is generated from mouse immunized with MYO1C recombinant protein. |
| Cellular Localization | Cytoplasm. Cell membrane (By similarity). Cell projection, stereocilium membrane (By similarity) Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 in actin-based membranes. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity) |
| Entrez Gene | 4641 |
|---|---|
| Nucleotide Accession | NP_203693.3 NP_001074248.1 |
Application
MYO1C (Cat. #AM1905a) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the MYO1C antibody detected the MYO1C protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
