Application
NCOA3 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NCOA3 antibody detected the NCOA3 protein (arrow).| Product Name | NCOA3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; ACTR; Amplified in breast cancer 1 protein; CBP-interacting protein; Class E basic helix-loop-helix protein 42; Receptor-associated coactivator 3; Steroid receptor coactivator protein 3; Th |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | AIB1 BHLHE42 RAC3 TRAM1 |
|---|---|
| Alternative Names | NCOA3 AIB1 BHLHE42 RAC3 TRAM1 Nuclear receptor coactivator 3 ACTR Amplified in breast cancer 1 protein CBP-interacting protein Class E basic helix-loop-helix protein 42 Receptor-associated coactivator 3 Steroid receptor coactivator protein 3 Th |
| Molecular Weight(MW) | 155293 Da |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9 |
| Tissue Specificity | Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney |
| Cellular Localization | Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus |
| Entrez Gene | 8202 |
|---|---|
| Nucleotide Accession | NP_001167559.1 |
Application
NCOA3 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the NCOA3 antibody detected the NCOA3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
