Application
A. Western blot analysis on mouse brain lysates using anti-Phospho-NMDAR1 (pS889) RabMAb (Cat. #AJ1546a), 1:2000 dilution. Cells were either (A) untreated (B) treated with APApplication
B. Immunohistochemical analysis of paraffin-embedded human brain using anti-NMDAR1 RabMAb (Cat. #AJ1546a).| Product Name | NMDAR1 Antibody Phospho (pS889) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification | p-S889 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EPR2480Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:2000~5000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NMDAR1 |
|---|---|
| Alternative Names | GRIN1 NMDAR1 Glutamate [NMDA] receptor subunit zeta-1 N-methyl-D-aspartate receptor subunit NR1 |
| Molecular Weight(MW) | 105373 Da |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity) |
| Tissue Specificity | A phospho specific peptide corresponding to residues surrounding serine 889 of human NMDAR1 was used as an immunogen. This antibody detects NMDAR1 phosphorylated at serine 889. |
| Cellular Localization | Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (By similarity) |
| Entrez Gene | 2902 |
|---|
Application
A. Western blot analysis on mouse brain lysates using anti-Phospho-NMDAR1 (pS889) RabMAb (Cat. #AJ1546a), 1:2000 dilution. Cells were either (A) untreated (B) treated with AP
Application
B. Immunohistochemical analysis of paraffin-embedded human brain using anti-NMDAR1 RabMAb (Cat. #AJ1546a).| Application Notes | WB:1:2000~5000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
