Application
OPTN Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the OPTN antibody detected the OPTN protein (arrow).| Product Name | OPTN Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | OPTN; FIP2; GLC1E; HIP7; HYPL; NRP; Optineurin; E3-14.7K-interacting protein; FIP-2; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; NEMO-related protein; Optic neuropathy-inducing protein; Transcription fact |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FIP2 GLC1E HIP7 HYPL NRP |
|---|---|
| Alternative Names | OPTN FIP2 GLC1E HIP7 HYPL NRP Optineurin E3-14.7K-interacting protein FIP-2 Huntingtin yeast partner L Huntingtin-interacting protein 7 Huntingtin-interacting protein L NEMO-related protein Optic neuropathy-inducing protein Transcription fact |
| Molecular Weight(MW) | 65921 Da |
| Function | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death |
| Tissue Specificity | Present in acqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta |
| Cellular Localization | Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Note=Found in the perinuclear region and associates with the Golgi apparatus Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane |
| Entrez Gene | 10133 |
|---|---|
| Nucleotide Accession | NP_068815.2 |
Application
OPTN Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the OPTN antibody detected the OPTN protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
