Application
PGR/PR Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the PGR/PR antibody detected the PGR/PR protein (arrow).Application
PGR/PR Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PGR/PR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | PGR/PR Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PGR; NR3C3; Progesterone receptor; Nuclear receptor subfamily 3 group C member 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NR3C3 |
|---|---|
| Alternative Names | PGR NR3C3 Progesterone receptor Nuclear receptor subfamily 3 group C member 3 |
| Molecular Weight(MW) | 98981 Da |
| Function | The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation |
| Tissue Specificity | This PGR/PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-377 amino acids from the Central region of human PGR/PR. |
| Cellular Localization | Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases |
| Entrez Gene | 5241 |
|---|---|
| Nucleotide Accession | NP_000917.3 |
Application
PGR/PR Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the PGR/PR antibody detected the PGR/PR protein (arrow).
Application
PGR/PR Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PGR/PR Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
