| Product Name | Progesterone Receptor antibody , C-term |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Mouse Monoclonal antibody [C262] to Progesterone Receptor (C-term)Progesterone plays a central role in the reproductive events associated with the establishment and maintenance of pregnancy. Progesterone receptor, a member of the steroid receptor superfamily, mediates the physiologic effects of progesterone. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. Although PRA and PRB share several structural domains, they are distinct transcription factors that mediate their own response genes and physiologic effects with little overlap |
| Immunogen | Synthetic peptide to C-terminal tail of human progesterone receptor (PR). (aa 919-933 ILAGMVKPLLFHKK) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | C262 |
| Host Species | Mouse |
| Tested Applications | IPWB |
| Use at 5-10µg/ml: |
|
| Species Reactivity | HumanMouseRatRabbit |
| Concentration | 1mg/ml (Please refer to the vial label for the specific concentration) |
| Purification | Protein G |
| Gene Synonyms | NR3C3 PR |
|---|---|
| Target | Progesterone Receptor |
| Tissue Specificity | Human PR-A and PR-B isoforms. Cross reacts with mouse, rat and rabbit PR |
| Cellular Localization | Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases. Mainly nuclear. |
| Application Notes | Use at 5-10µg/ml: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 2-8°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | PBS + 0.1% sodium azide |
