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PI3-kinase (p110) Antibody (subunit beta) (N-term)
Catalog Number:OM217832
OM217832
Discount Price
OM217832-100ul
1~2 Week
100ul
OM217832-50ul
50ul
OM217832-20ul
20ul
1~2 Week
Product Profile
Product Name PI3-kinase (p110) Antibody (subunit beta) (N-term)
Antibody Type Primary Antibodies
Antigen Alias PIK3CB, PIK3C1, Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase p110 subunit beta;PtdIns-3-kinase p110;PI3Kbeta
Key Feature
Clonality Monoclonal
Clone Number Y384
Host Species Rabbit
Tested Applications WB
WB:1:500
Species Reactivity Human
Concentration 1mg/ml
Target Information
Gene Synonyms PIK3C1
Alternative Names PIK3CB
PIK3C1
Phosphatidylinositol-4
5-bisphosphate 3-kinase catalytic subunit beta isoform
PI3-kinase p110 subunit beta
PtdIns-3-kinase p110
PI3Kbeta
Molecular Weight(MW) 122762 Da
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors
Tissue Specificity Expressed ubiquitously.
Cellular Localization Cytoplasm. Nucleus. Note=Interaction with PIK3R2 is required for nuclear localization and export
Database Links
Entrez Gene 5291
Application

Application

A. Western blot analysis on Jurkat cell lysate using anti-PI3-kinase p110 subunit beta (N-term) RabMAb (Cat. #AJ1607b), dilution 1:500.
Application Notes WB:1:500
Additional Information
Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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