Application
Western blot analysis of anti-PINK1 Monoclonal Antibody (AM6406a) in mouse brain tissue lysates. PINK1(arrow) was detected using the ascites Mab. (dilution 1:500)Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PINK1 Monoclonal Antibody (Cat.#AM6406a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.Application
Formalin-fixed and paraffin-embedded human Brain Cortex tissue reacted with PINK1 Monoclonal Antibody (Cat.#AM6406a), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | PINK1 Antibody (Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | PINK1; Serine/threonine-protein kinase PINK1, mitochondrial; BRPK; PTEN-induced putative kinase protein 1 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | 38CT20.8.5 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500~2000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | PINK1 Serine/threonine-protein kinase PINK1 mitochondrial BRPK PTEN-induced putative kinase protein 1 |
|---|---|
| Molecular Weight(MW) | 62769 Da |
| Function | Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation |
| Tissue Specificity | Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development |
| Cellular Localization | Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol |
| Entrez Gene | 65018 |
|---|
Application
Western blot analysis of anti-PINK1 Monoclonal Antibody (AM6406a) in mouse brain tissue lysates. PINK1(arrow) was detected using the ascites Mab. (dilution 1:500)
Application
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PINK1 Monoclonal Antibody (Cat.#AM6406a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application
Formalin-fixed and paraffin-embedded human Brain Cortex tissue reacted with PINK1 Monoclonal Antibody (Cat.#AM6406a), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | WB:1:500~2000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
