Application
RAB25 Antibody (Center) western blot analysis in mouse stomach,bladder tissue lysates (35ug/lane).This demonstrates the RAB25 antibody detected the RAB25 protein (arrow).| Product Name | RAB25 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RAB25; CATX8; Ras-related protein Rab-25; CATX-8 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CATX8 |
|---|---|
| Alternative Names | RAB25 CATX8 Ras-related protein Rab-25 CATX-8 |
| Molecular Weight(MW) | 23496 Da |
| Function | Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway Together with MYO5B regulates transcytosis (By similarity) |
| Tissue Specificity | Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cell projection, pseudopodium membrane Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips |
| Entrez Gene | 57111 |
|---|---|
| Nucleotide Accession | NP_065120.2 |
Application
RAB25 Antibody (Center) western blot analysis in mouse stomach,bladder tissue lysates (35ug/lane).This demonstrates the RAB25 antibody detected the RAB25 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
