Application
RAPGEF3 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RAPGEF3 antibody detected the RAPGEF3 protein (arrow).Application
RAPGEF3 Antibody (N-term) (AP14670a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAPGEF3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | RAPGEF3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RAPGEF3; CGEF1; EPAC; EPAC1; Rap guanine nucleotide exchange factor 3; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; cAMP-regulated guanine n |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CGEF1 EPAC EPAC1 |
|---|---|
| Alternative Names | RAPGEF3 CGEF1 EPAC EPAC1 Rap guanine nucleotide exchange factor 3 Exchange factor directly activated by cAMP 1 Exchange protein directly activated by cAMP 1 Rap1 guanine-nucleotide-exchange factor directly activated by cAMP cAMP-regulated guanine n |
| Molecular Weight(MW) | 103751 Da |
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis |
| Tissue Specificity | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney |
| Cellular Localization | Endomembrane system. |
| Nucleotide Accession | NP_001092001.1 |
|---|
Application
RAPGEF3 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RAPGEF3 antibody detected the RAPGEF3 protein (arrow).
Application
RAPGEF3 Antibody (N-term) (AP14670a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAPGEF3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
