Application
RUVBL1 Antibody (Cat. #AM2039b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RUVBL1 antibody detected the RUVBL1 protein (arrow).| Product Name | RUVBL1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RUVBL1; INO80H; NMP238; TIP49; TIP49A; RuvB-like 1; 49 kDa TATA box-binding protein-interacting protein; 54 kDa erythrocyte cytosolic protein; INO80 complex subunit H; Nuclear matrix protein 238; Pontin 52; TIP49a; TIP60-associated protein 54-alpha |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 507CT2.2.2 |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | INO80H NMP238 TIP49 TIP49A |
|---|---|
| Alternative Names | RUVBL1 INO80H NMP238 TIP49 TIP49A RuvB-like 1 49 kDa TATA box-binding protein-interacting protein 54 kDa erythrocyte cytosolic protein INO80 complex subunit H Nuclear matrix protein 238 Pontin 52 TIP49a TIP60-associated protein 54-alpha |
| Molecular Weight(MW) | 50228 Da |
| Function | Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair May be able to bind plasminogen at cell surface and enhance plasminogen activation |
| Tissue Specificity | Ubiquitously expressed with high expression in heart, skeletal muscle and testis |
| Cellular Localization | Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, centrosome Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells |
| Entrez Gene | 8607 |
|---|---|
| Nucleotide Accession | NP_003698.1 |
Application
RUVBL1 Antibody (Cat. #AM2039b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RUVBL1 antibody detected the RUVBL1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
