Application
SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).| Product Name | SCRIB Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SCRIB; CRIB1; KIAA0147; LAP4; SCRB1; VARTUL; Protein scribble homolog; Protein LAP4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CRIB1 KIAA0147 LAP4 SCRB1 VARTUL |
|---|---|
| Alternative Names | SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL Protein scribble homolog Protein LAP4 |
| Molecular Weight(MW) | 174885 Da |
| Function | Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity |
| Tissue Specificity | Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level) |
| Cellular Localization | Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre- synaptic regions |
| Entrez Gene | 23513 |
|---|---|
| Nucleotide Accession | NP_874365.2 |
Application
SCRIB Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the SCRIB antibody detected the SCRIB protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
