Application
SET1B Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SET1B antibody detected the SET1B protein (arrow).| Product Name | SET1B Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SETD1B; KIAA1076; KMT2G; SET1B; Histone-lysine N-methyltransferase SETD1B; Lysine N-methyltransferase 2G; SET domain-containing protein 1B |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA1076 KMT2G SET1B |
|---|---|
| Alternative Names | SETD1B KIAA1076 KMT2G SET1B Histone-lysine N-methyltransferase SETD1B Lysine N-methyltransferase 2G SET domain-containing protein 1B |
| Molecular Weight(MW) | 208732 Da |
| Function | Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression Specifically tri-methylates 'Lys-4' of histone H3 in vitro |
| Tissue Specificity | This SET1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685-720 amino acids from the C-terminal region of human SET1B. |
| Cellular Localization | Nucleus speckle. Chromosome. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes |
| Entrez Gene | 23067 |
|---|---|
| Nucleotide Accession | NP_055863.1 |
Application
SET1B Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the SET1B antibody detected the SET1B protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
