Application
SH3PXD2A Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SH3PXD2A antibody detected the SH3PXD2A protein (arrow).| Product Name | SH3PXD2A Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SH3PXD2A; FISH; KIAA0418; SH3MD1; TKS5; SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | FISH KIAA0418 SH3MD1 TKS5 |
|---|---|
| Alternative Names | SH3PXD2A FISH KIAA0418 SH3MD1 TKS5 SH3 and PX domain-containing protein 2A Adapter protein TKS5 Five SH3 domain-containing protein SH3 multiple domains protein 1 Tyrosine kinase substrate with five SH3 domains |
| Molecular Weight(MW) | 125289 Da |
| Function | Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide |
| Tissue Specificity | Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas |
| Cellular Localization | Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells |
| Entrez Gene | 9644 |
|---|---|
| Nucleotide Accession | NP_055446.2 |
Application
SH3PXD2A Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SH3PXD2A antibody detected the SH3PXD2A protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
