Application
A. Western blot analysis of anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a) 1:1,000 dilution A- A431 B- Jurkat C- K562Application
B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a).| Product Name | SHP-1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | Y476 |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:1000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | HCP, PTP1C |
|---|---|
| Alternative Names | PTPN6 HCP PTP1C Tyrosine-protein phosphatase non-receptor type 6 Hematopoietic cell protein-tyrosine phosphatase SH-PTP1 Protein-tyrosine phosphatase SHP-1 |
| Molecular Weight(MW) | 67561 Da |
| Function | Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis |
| Tissue Specificity | Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells |
| Cellular Localization | Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1 |
| Entrez Gene | 5777 |
|---|
Application
A. Western blot analysis of anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a) 1:1,000 dilution A- A431 B- Jurkat C- K562
Application
B. Immunohistochemical analysis of paraffin-embedded human lymph node using anti-SHP-1 (C-term) RabMAb (Cat. #AJ1715a).| Application Notes | WB:1:1000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
