Application
SOCS7 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SOCS7 antibody detected the SOCS7 protein (arrow).| Product Name | SOCS7 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SOCS7; NAP4; SOCS6; Suppressor of cytokine signaling 7; Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | NAP4 SOCS6 |
|---|---|
| Alternative Names | SOCS7 NAP4 SOCS6 Suppressor of cytokine signaling 7 Nck Ash and phospholipase C gamma-binding protein Nck-associated protein 4 |
| Molecular Weight(MW) | 62969 Da |
| Function | Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF- like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) |
| Tissue Specificity | Expressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain |
| Cellular Localization | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus Rapidly relocalizes to the nucleus after UV irradiation Cytoplasmic location depends upon SEPT7 presence |
| Entrez Gene | 30837 |
|---|---|
| Nucleotide Accession | NP_055413.1 |
Application
SOCS7 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SOCS7 antibody detected the SOCS7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
