Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate| Product Name | Rabbit anti-SOCS7 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | NAP4, NCKAP4 |
| Immunogen | The immunogen for anti-SOCS7 antibody: synthetic peptide directed towards the N terminal of human SOCS7 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | BovineHumanMousePigRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SOCS7 |
|---|---|
| Gene Synonyms | NAP4 NCKAP4 |
| Gene Full Name | Suppressor of cytokine signaling 7 |
| Gene Summary | SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Alternative Names | NAP4 NCKAP4 |
| Molecular Weight(MW) | 64kDa |
| Sequence | 581 amino acids |
Western blot
0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: OVCAR-3 cell lysate| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
