Application
Figure 1: Western blot analysis using anti-SORL1 mAb against truncated SORL1 recombinant protein.Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebrum tissues using anti-SORL1 mAb with DAB staining.Application
Figure 3: Immunohistochemical analysis of paraffin-embedded human brain, cortex tissues using anti-SORL1 mAb.| Product Name | SORL1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SORL1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 3B6B11 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500 - 2000. IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C11orf32 |
|---|---|
| Alternative Names | SORL1 |
| Molecular Weight(MW) | 248426 Da |
| Function | Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction |
| Tissue Specificity | Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals |
| Cellular Localization | Membrane; Single-pass type I membrane protein (Potential) |
| Entrez Gene | 6653 |
|---|---|
| Nucleotide Accession | NP_003096.1 |
Application
Figure 1: Western blot analysis using anti-SORL1 mAb against truncated SORL1 recombinant protein.
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human cerebrum tissues using anti-SORL1 mAb with DAB staining.
Application
Figure 3: Immunohistochemical analysis of paraffin-embedded human brain, cortex tissues using anti-SORL1 mAb.| Application Notes | WB:1:500 - 2000. IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human SORL1 expressed in E. Coli. |
