Application
Figure 1: Western blot analysis using anti-SRA monoclonal antiobdy against truncated SRA recombinant protein(1), human ovary cancer tissue lysate(2) and A431 cell lysate(3).Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human skin carcinoma(left) and breast carcinoma(right), showing cytoplasmic and membrane localization using anti-SRA antibody with DAB staining.| Product Name | SRA Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SRAP; STRAA1 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 1D4H8 |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500 - 2000. IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | SRAP STRAA1 |
|---|---|
| Molecular Weight(MW) | 25673 Da |
| Function | Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis |
| Tissue Specificity | Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus |
| Cellular Localization | Nucleus. Cytoplasm. |
| Entrez Gene | 10011 |
|---|---|
| Nucleotide Accession | NP_001030312.2 |
Application
Figure 1: Western blot analysis using anti-SRA monoclonal antiobdy against truncated SRA recombinant protein(1), human ovary cancer tissue lysate(2) and A431 cell lysate(3).
Application
Figure 2: Immunohistochemical analysis of paraffin-embedded human skin carcinoma(left) and breast carcinoma(right), showing cytoplasmic and membrane localization using anti-SRA antibody with DAB staining.| Application Notes | WB:1:500 - 2000. IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of SRA expressed in E. Coli. |
